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Research Article


Impact of dexamethasone on cortisol and luteinizing hormone levels in dairy goats with subclinical mastitis in Siliragung District, Banyuwangi

Amung Logam Saputro, Ragil Angga Prastiya, Muhammad Thohawi Elziyad Purnama, Ratih Novita Praja, Wiwik Misaco Yuniarti, Salipudin Tasil Maslamama, Azhar Burhanuddin, Deborah Michelle Immanuela, Siti Nur Fadhila.


Abstract
Background:
Dairy goats are small ruminants with high potential in the livestock industry but are susceptible to mastitis infection, which can reduce milk productivity. Dexamethasone is one therapy used in the treatment of mastitis. Its excessive use can cause oxidative stress, inhibit follicle development, and interfere with reproduction. The stress experienced due to mastitis also increases cortisol hormone levels and decreases LH levels.

Aim:
This study aimed to evaluate the effect of dexamethasone administration on luteinizing hormone (LH) and cortisol levels in dairy goats with subclinical mastitis.

Method:
This research is a laboratory experimental study with completely randomized design. A total of 20 dairy goats with subclinical mastitis were divided into five treatment groups. C- group was given physiological NaCl 0.9%; C+ was given Flunixin Meglumine® 1,5 mg/kgBW, whereas the treatment group was given dexamethasone at a dose of 0.04 mg/kgBW (T1), 0.1 mg/kgBW (T2), and 0.12 mg/kgBW (T3) via intramuscular for five consecutive days. Blood samples were taken from the jugular vein on the sixth day. LH and cortisol levels were tested using an enzyme-linked
immunosorbent assay.

Results:
The administration of dexamethasone at a toxic dose of 0.12 mg/kgBW and Flunixin Meglumine® at a therapeutic dose of 50 mg/kgBW significantly reduced LH levels. In addition, statistical analysis with the one-way ANOVA test showed that dexamethasone administration decreased cortisol levels (p < 0.05). Duncan’s post hoc test showed significant differences between treatment groups and negative and positive controls (p < 0.005).

Conclusion:
Dexamethasone administration to dairy goats with subclinical mastitis can reduce LH and cortisol levels, potentially affecting livestock reproduction and productivity.

Key words: Dairy goats, Subclinical mastitis, Dexamethasone, LH hormone, Cortisol


 
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How to Cite this Article
Pubmed Style

Saputro AL, Prastiya RA, Purnama MTE, Praja RN, Yuniarti WM, Maslamama ST, Burhanuddin A, Immanuela DM, Fadhila SN. Impact of dexamethasone on cortisol and luteinizing hormone levels in dairy goats with subclinical mastitis in Siliragung District, Banyuwangi. Open Vet. J.. 2025; 15(8): 3459-3467. doi:10.5455/OVJ.2025.v15.i8.9

Web Style

Saputro AL, Prastiya RA, Purnama MTE, Praja RN, Yuniarti WM, Maslamama ST, Burhanuddin A, Immanuela DM, Fadhila SN. Impact of dexamethasone on cortisol and luteinizing hormone levels in dairy goats with subclinical mastitis in Siliragung District, Banyuwangi. https://www.openveterinaryjournal.com/?mno=253816 [Access: September 01, 2025]. doi:10.5455/OVJ.2025.v15.i8.9

AMA (American Medical Association) Style

Saputro AL, Prastiya RA, Purnama MTE, Praja RN, Yuniarti WM, Maslamama ST, Burhanuddin A, Immanuela DM, Fadhila SN. Impact of dexamethasone on cortisol and luteinizing hormone levels in dairy goats with subclinical mastitis in Siliragung District, Banyuwangi. Open Vet. J.. 2025; 15(8): 3459-3467. doi:10.5455/OVJ.2025.v15.i8.9


Vancouver/ICMJE Style

Saputro AL, Prastiya RA, Purnama MTE, Praja RN, Yuniarti WM, Maslamama ST, Burhanuddin A, Immanuela DM, Fadhila SN. Impact of dexamethasone on cortisol and luteinizing hormone levels in dairy goats with subclinical mastitis in Siliragung District, Banyuwangi. Open Vet. J.. (2025), [cited September 01, 2025]; 15(8): 3459-3467. doi:10.5455/OVJ.2025.v15.i8.9


Harvard Style

Saputro, A. L., Prastiya, . R. A., Purnama, . M. T. E., Praja, . R. N., Yuniarti, . W. M., Maslamama, . S. T., Burhanuddin, . A., Immanuela, . D. M. & Fadhila, . S. N. (2025) Impact of dexamethasone on cortisol and luteinizing hormone levels in dairy goats with subclinical mastitis in Siliragung District, Banyuwangi. Open Vet. J., 15 (8), 3459-3467. doi:10.5455/OVJ.2025.v15.i8.9


Turabian Style

Saputro, Amung Logam, Ragil Angga Prastiya, Muhammad Thohawi Elziyad Purnama, Ratih Novita Praja, Wiwik Misaco Yuniarti, Salipudin Tasil Maslamama, Azhar Burhanuddin, Deborah Michelle Immanuela, and Siti Nur Fadhila. 2025. Impact of dexamethasone on cortisol and luteinizing hormone levels in dairy goats with subclinical mastitis in Siliragung District, Banyuwangi. Open Veterinary Journal, 15 (8), 3459-3467. doi:10.5455/OVJ.2025.v15.i8.9


Chicago Style

Saputro, Amung Logam, Ragil Angga Prastiya, Muhammad Thohawi Elziyad Purnama, Ratih Novita Praja, Wiwik Misaco Yuniarti, Salipudin Tasil Maslamama, Azhar Burhanuddin, Deborah Michelle Immanuela, and Siti Nur Fadhila. "Impact of dexamethasone on cortisol and luteinizing hormone levels in dairy goats with subclinical mastitis in Siliragung District, Banyuwangi." Open Veterinary Journal 15 (2025), 3459-3467. doi:10.5455/OVJ.2025.v15.i8.9


MLA (The Modern Language Association) Style

Saputro, Amung Logam, Ragil Angga Prastiya, Muhammad Thohawi Elziyad Purnama, Ratih Novita Praja, Wiwik Misaco Yuniarti, Salipudin Tasil Maslamama, Azhar Burhanuddin, Deborah Michelle Immanuela, and Siti Nur Fadhila. "Impact of dexamethasone on cortisol and luteinizing hormone levels in dairy goats with subclinical mastitis in Siliragung District, Banyuwangi." Open Veterinary Journal 15.8 (2025), 3459-3467. Print. doi:10.5455/OVJ.2025.v15.i8.9


APA (American Psychological Association) Style

Saputro, A. L., Prastiya, . R. A., Purnama, . M. T. E., Praja, . R. N., Yuniarti, . W. M., Maslamama, . S. T., Burhanuddin, . A., Immanuela, . D. M. & Fadhila, . S. N. (2025) Impact of dexamethasone on cortisol and luteinizing hormone levels in dairy goats with subclinical mastitis in Siliragung District, Banyuwangi. Open Veterinary Journal, 15 (8), 3459-3467. doi:10.5455/OVJ.2025.v15.i8.9


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