Effect of nanocurcumin administration on renal TGF-β expression and liver histopathological features in noise-stressed pregnant mice

Viski Fitri Hendrawan; Ezra Rahadian Rusdi; Intan Firdha Olien; Marwah Azrianti Maulidia; Yudit Oktanella; Aulia Firmawati; Herlina Pratiwi

doi:10.5455/OVJ.2026.v16.i9.17

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Open Vet. J.. 2026; 16(9): 6098-6105

doi: 10.5455/OVJ.2026.v16.i9.17

Effect of nanocurcumin administration on renal TGF-β expression and liver histopathological features in noise-stressed pregnant mice

Viski Fitri Hendrawan, Ezra Rahadian Rusdi, Intan Firdha Olien, Marwah Azrianti Maulidia, Yudit Oktanella, Aulia Firmawati, Herlina Pratiwi.

Abstract
Background:
Stress is a physiological response that enables animals to adapt to both internal and external stressors. Continuous exposure to intense noise during pregnancy may disrupt homeostasis and induce oxidative and inflammatory injury in maternal organs.

Aim:
This study aimed to evaluate the effect of nanocurcumin administration on transforming growth factor-beta (TGF-β) expression in kidney tissue and histopathological changes in the liver of pregnant mice exposed to noise stress.

Methods:
Twenty-five pregnant mice were randomly allocated into five groups (n = 5/group): K(–), untreated control; K(+), exposed to 135 decibels noise for 40 minutes/day; P1, noise + nanocurcumin 14 mg/kg body weight (BW); P2, noise + nanocurcumin 21 mg/kg BW; and P3, noise + nanocurcumin 24.5 mg/kg BW. Oral treatments were administered from gestational day 6 to 18. Kidney sections were examined immunohistochemically for TGF-β expression, and liver tissues were evaluated using hematoxylin-eosin staining.

Results:
Noise exposure was associated with increased renal TGF-β expression and greater liver histopathological damage. The P3 group showed TGF-β expression that was not significantly different from that in the negative control group. The liver histopathological scoring also showed lower degeneration and necrosis scores in P3, approaching those of the negative control group.

Conclusion:
Nanocurcumin administration was associated with lower renal TGF-β expression and less severe liver tissue injury in pregnant mice exposed to high-intensity noise. These findings suggest that nanocurcumin may have protective potential against noise-induced oxidative and inflammatory changes during pregnancy. In a broader context, this study may contribute to Sustainable Development Goal (SDG) 3 (Good Health and Well-being) by supporting maternal health under stress conditions and to SDG 12 (Responsible Consumption and Production) by promoting further research on plant-derived bioactive compounds as potential protective agents.

Key words: Good health and well-being; Kidney; Liver; Responsible consumption and production; TGF-β.

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How to Cite this Article

Pubmed Style

Hendrawan VF, Rusdi ER, Olien IF, Maulidia MA, Oktanella Y, Firmawati A, Pratiwi H. Effect of nanocurcumin administration on renal TGF-β expression and liver histopathological features in noise-stressed pregnant mice. Open Vet. J.. 2026; 16(9): 6098-6105. doi:10.5455/OVJ.2026.v16.i9.17

Web Style

Hendrawan VF, Rusdi ER, Olien IF, Maulidia MA, Oktanella Y, Firmawati A, Pratiwi H. Effect of nanocurcumin administration on renal TGF-β expression and liver histopathological features in noise-stressed pregnant mice. https://www.openveterinaryjournal.com/?mno=306748 [Access: September 16, 2026]. doi:10.5455/OVJ.2026.v16.i9.17

AMA (American Medical Association) Style

Hendrawan VF, Rusdi ER, Olien IF, Maulidia MA, Oktanella Y, Firmawati A, Pratiwi H. Effect of nanocurcumin administration on renal TGF-β expression and liver histopathological features in noise-stressed pregnant mice. Open Vet. J.. 2026; 16(9): 6098-6105. doi:10.5455/OVJ.2026.v16.i9.17

Vancouver/ICMJE Style

Hendrawan VF, Rusdi ER, Olien IF, Maulidia MA, Oktanella Y, Firmawati A, Pratiwi H. Effect of nanocurcumin administration on renal TGF-β expression and liver histopathological features in noise-stressed pregnant mice. Open Vet. J.. (2026), [cited September 16, 2026]; 16(9): 6098-6105. doi:10.5455/OVJ.2026.v16.i9.17

Harvard Style

Hendrawan, V. F., Rusdi, . E. R., Olien, . I. F., Maulidia, . M. A., Oktanella, . Y., Firmawati, . A. & Pratiwi, . H. (2026) Effect of nanocurcumin administration on renal TGF-β expression and liver histopathological features in noise-stressed pregnant mice. Open Vet. J., 16 (9), 6098-6105. doi:10.5455/OVJ.2026.v16.i9.17

Turabian Style

Hendrawan, Viski Fitri, Ezra Rahadian Rusdi, Intan Firdha Olien, Marwah Azrianti Maulidia, Yudit Oktanella, Aulia Firmawati, and Herlina Pratiwi. 2026. Effect of nanocurcumin administration on renal TGF-β expression and liver histopathological features in noise-stressed pregnant mice. Open Veterinary Journal, 16 (9), 6098-6105. doi:10.5455/OVJ.2026.v16.i9.17

Chicago Style

Hendrawan, Viski Fitri, Ezra Rahadian Rusdi, Intan Firdha Olien, Marwah Azrianti Maulidia, Yudit Oktanella, Aulia Firmawati, and Herlina Pratiwi. "Effect of nanocurcumin administration on renal TGF-β expression and liver histopathological features in noise-stressed pregnant mice." Open Veterinary Journal 16 (2026), 6098-6105. doi:10.5455/OVJ.2026.v16.i9.17

MLA (The Modern Language Association) Style

APA (American Psychological Association) Style

Hendrawan, V. F., Rusdi, . E. R., Olien, . I. F., Maulidia, . M. A., Oktanella, . Y., Firmawati, . A. & Pratiwi, . H. (2026) Effect of nanocurcumin administration on renal TGF-β expression and liver histopathological features in noise-stressed pregnant mice. Open Veterinary Journal, 16 (9), 6098-6105. doi:10.5455/OVJ.2026.v16.i9.17

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