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Research Article


Therapeutic effects of Clitoria ternatea extract alone and combined with Nifedipine in an L-NAME-induced preeclampsia rat model

Ajeng Maharani Pratiwi, Soetrisno Soetrisno, Bambang Purwanto, Brian Wasita.


Abstract
Background:
Preeclampsia (PE) syndrome remains a leading cause of maternal and neonatal mortality worldwide. Several studies have shown that PE is characterized by hypertensive disorders, which affect 5%–10% of pregnancies. Despite the high mortality rate, there are currently limited alternative treatments for PE.

Aim:
This study aimed to evaluate the therapeutic efficacy of butterfly pea flower (Clitoria ternatea) and nifedipine, at both single and combination doses, in Wistar rats with PE.

Methods:
Animals were induced using Nω-Nitro-L-Arginine Methyl Ester Hydrochloride (L-NAME) for 5 days. Nifedipine (0.54 mg/kg body weight) and butterfly pea flower extract (300 mg/kg) were administered for 14 days. On days 0, 5, 12, and 19 of pregnancy, the rats were examined for blood pressure and albuminuria levels, followed by sacrifice on day 19. The levels of interleukin-6 (IL-6), malondialdehyde (MDA), cysteine-aspartic proteases–3 (caspase-3), blood pressure, albuminuria, and spiral artery histology were examined. ANOVA was used to identify differences between groups, followed by a post hoc test to pinpoint the variables that differed the most significantly.

Results:
The combination of butterfly pea flower extract and nifedipine significantly reduced IL-6, MDA, caspase-3, blood pressure, and albuminuria; however, placental histological analysis revealed no significant differences in SAD.

Conclusion:
Based on these findings, the administration of butterfly pea flower ethanol extract can serve as a complementary therapy to improve the prognosis of PE.

Key words: Ethanol extract of butterfly pea flower; Nifedipine; Preeclampsia; Rat model; L-NAME.


 
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How to Cite this Article
Pubmed Style

Pratiwi AM, Soetrisno S, Purwanto B, Wasita B. Therapeutic effects of Clitoria ternatea extract alone and combined with Nifedipine in an L-NAME-induced preeclampsia rat model. Open Vet. J.. 2026; 16(7): 4388-4396. doi:10.5455/OVJ.2026.v16.i7.25

Web Style

Pratiwi AM, Soetrisno S, Purwanto B, Wasita B. Therapeutic effects of Clitoria ternatea extract alone and combined with Nifedipine in an L-NAME-induced preeclampsia rat model. https://www.openveterinaryjournal.com/?mno=313687 [Access: July 11, 2026]. doi:10.5455/OVJ.2026.v16.i7.25

AMA (American Medical Association) Style

Pratiwi AM, Soetrisno S, Purwanto B, Wasita B. Therapeutic effects of Clitoria ternatea extract alone and combined with Nifedipine in an L-NAME-induced preeclampsia rat model. Open Vet. J.. 2026; 16(7): 4388-4396. doi:10.5455/OVJ.2026.v16.i7.25


Vancouver/ICMJE Style

Pratiwi AM, Soetrisno S, Purwanto B, Wasita B. Therapeutic effects of Clitoria ternatea extract alone and combined with Nifedipine in an L-NAME-induced preeclampsia rat model. Open Vet. J.. (2026), [cited July 11, 2026]; 16(7): 4388-4396. doi:10.5455/OVJ.2026.v16.i7.25


Harvard Style

Pratiwi, A. M., Soetrisno, . S., Purwanto, . B. & Wasita, . B. (2026) Therapeutic effects of Clitoria ternatea extract alone and combined with Nifedipine in an L-NAME-induced preeclampsia rat model. Open Vet. J., 16 (7), 4388-4396. doi:10.5455/OVJ.2026.v16.i7.25


Turabian Style

Pratiwi, Ajeng Maharani, Soetrisno Soetrisno, Bambang Purwanto, and Brian Wasita. 2026. Therapeutic effects of Clitoria ternatea extract alone and combined with Nifedipine in an L-NAME-induced preeclampsia rat model. Open Veterinary Journal, 16 (7), 4388-4396. doi:10.5455/OVJ.2026.v16.i7.25


Chicago Style

Pratiwi, Ajeng Maharani, Soetrisno Soetrisno, Bambang Purwanto, and Brian Wasita. "Therapeutic effects of Clitoria ternatea extract alone and combined with Nifedipine in an L-NAME-induced preeclampsia rat model." Open Veterinary Journal 16 (2026), 4388-4396. doi:10.5455/OVJ.2026.v16.i7.25


MLA (The Modern Language Association) Style

Pratiwi, Ajeng Maharani, Soetrisno Soetrisno, Bambang Purwanto, and Brian Wasita. "Therapeutic effects of Clitoria ternatea extract alone and combined with Nifedipine in an L-NAME-induced preeclampsia rat model." Open Veterinary Journal 16.7 (2026), 4388-4396. Print. doi:10.5455/OVJ.2026.v16.i7.25


APA (American Psychological Association) Style

Pratiwi, A. M., Soetrisno, . S., Purwanto, . B. & Wasita, . B. (2026) Therapeutic effects of Clitoria ternatea extract alone and combined with Nifedipine in an L-NAME-induced preeclampsia rat model. Open Veterinary Journal, 16 (7), 4388-4396. doi:10.5455/OVJ.2026.v16.i7.25


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