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2024, Vol: 14, Issue: 11
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Research Article


Promising antiviral inhibitors against lumpy skin disease: A vetinformatics approach

S. Vamshi Krishna, Aniket Sarkar, Suchandan Banerjee, Anindya Sundar Panja.


Abstract
Background:
Lumpy skin disease (LSD) is a transboundary virus disease that mostly affects cattle. It has recently reported all over the world, which highlights the need for efficient control methods. LSD poses serious economic dangers worldwide.

Aim:
The aim of this study was to screen novel antiviral compounds for the control of LSD.

Methods:
By using in silico approach, ADMET, docking, and molecular simulations, this work was designed to investigate 13 active compounds for antiviral effects against LSDV.

Results:
ADMET study of the selected 13 compounds revealed that Apigenin-4'-glucoside and Vidarabine did not show any critical hazards. The docking study identified potential antiviral compounds against LSDV, with Apigenin-4'-glucoside (ΔG = -6.6 ± 1.1) and Vidarabine (ΔG = -5.53 ± 0.73) showing promising interactions with key viral proteins. Molecular dynamics simulations confirmed the stability and robustness of these interactions, suggesting their potential as effective antiviral agents.

Conclusion:
Molecular analyses verify the strong antiviral activity of apigenin-4'-glucoside against LSDV among the selected compounds. This work sheds light on the way to explore potent anti-LSDV molecule. Moreover, the outcome of the study should screen after more extensive clinical studies.

Key words: Lumpy skin disease, ADMET, Antiviral, Molecular simulations


 
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How to Cite this Article
Pubmed Style

Krishna SV, Sarkar A, Banerjee S, Panja AS. Promising antiviral inhibitors against lumpy skin disease: A vetinformatics approach. Open Vet J. 2024; 14(11): 2806-2816. doi:10.5455/OVJ.2024.v14.i11.9

Web Style

Krishna SV, Sarkar A, Banerjee S, Panja AS. Promising antiviral inhibitors against lumpy skin disease: A vetinformatics approach. https://www.openveterinaryjournal.com/?mno=211312 [Access: December 06, 2024]. doi:10.5455/OVJ.2024.v14.i11.9

AMA (American Medical Association) Style

Krishna SV, Sarkar A, Banerjee S, Panja AS. Promising antiviral inhibitors against lumpy skin disease: A vetinformatics approach. Open Vet J. 2024; 14(11): 2806-2816. doi:10.5455/OVJ.2024.v14.i11.9


Vancouver/ICMJE Style

Krishna SV, Sarkar A, Banerjee S, Panja AS. Promising antiviral inhibitors against lumpy skin disease: A vetinformatics approach. Open Vet J. (2024), [cited December 06, 2024]; 14(11): 2806-2816. doi:10.5455/OVJ.2024.v14.i11.9


Harvard Style

Krishna, S. V., Sarkar, . A., Banerjee, . S. & Panja, . A. S. (2024) Promising antiviral inhibitors against lumpy skin disease: A vetinformatics approach. Open Vet J, 14 (11), 2806-2816. doi:10.5455/OVJ.2024.v14.i11.9


Turabian Style

Krishna, S. Vamshi, Aniket Sarkar, Suchandan Banerjee, and Anindya Sundar Panja. 2024. Promising antiviral inhibitors against lumpy skin disease: A vetinformatics approach. Open Veterinary Journal, 14 (11), 2806-2816. doi:10.5455/OVJ.2024.v14.i11.9


Chicago Style

Krishna, S. Vamshi, Aniket Sarkar, Suchandan Banerjee, and Anindya Sundar Panja. "Promising antiviral inhibitors against lumpy skin disease: A vetinformatics approach." Open Veterinary Journal 14 (2024), 2806-2816. doi:10.5455/OVJ.2024.v14.i11.9


MLA (The Modern Language Association) Style

Krishna, S. Vamshi, Aniket Sarkar, Suchandan Banerjee, and Anindya Sundar Panja. "Promising antiviral inhibitors against lumpy skin disease: A vetinformatics approach." Open Veterinary Journal 14.11 (2024), 2806-2816. Print. doi:10.5455/OVJ.2024.v14.i11.9


APA (American Psychological Association) Style

Krishna, S. V., Sarkar, . A., Banerjee, . S. & Panja, . A. S. (2024) Promising antiviral inhibitors against lumpy skin disease: A vetinformatics approach. Open Veterinary Journal, 14 (11), 2806-2816. doi:10.5455/OVJ.2024.v14.i11.9


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