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Research Article


Histomorphological evaluation of docetaxel effects on testes and epididymides in Wistar rats

Muntadher Salman Ashour, Ashwaq Ahmed Hussein, Entekhab Hameed Abed Al-shuwaili, Amer M. Hussin, Harith Humadi Khalaf.


Abstract
Background:
Chemotherapy drugs, such as Docetaxel, which are crucial for treating cancer, frequently cause unknowingly damage to healthy tissues.

Aim:
To investigate the histomorphological effects of docetaxel chemotherapy on certain parameters in testes and epididymides.

Method:
For this purpose, 24 Wistar Albino rats were divided randomly into one control group and three treatment groups. The treatment groups were administered 2.5, 5, and 10 mg/kg of the drug. The experiment lasted for 28 days. The weights of the testes and epididymides were measured. The testicular and epididymal samples were subjected to histological analysis and were examined under a light microscope.

Results:
The results revealed that the dose of DX1 (2.5 mg/kg) of docetaxel had no adverse effect on the process of spermatogenesis; however, the highest doses of DX2 and DX3 penetrated the blood-testis barrier and disrupted the structural and functional system of spermatogenesis. The results of the present study indicate that the highest dose of docetaxel leads to adverse effects on testes, epididymides, and their fertility parameters. In addition, the testicular tissues of DX2 and DX3 displayed adverse histomorphological changes. The process of spermatogenesis was interrupted, and a progressive decrease in the height of the germinal epithelium was observed. On this basis, the weight of the testes and epididymides decreased.

Conclusion:
A dose of 2.5 mg/kg of Docetaxel was the drug of choice for chemotherapy. Further studies are needed to investigate the long-term effects of Docetaxel on male fertility.

Key words: Docetaxel, Testis, Epididymis, Histomorphology, Wistar rat, Male fertility


 
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How to Cite this Article
Pubmed Style

Ashour MS, Hussein AA, Al-shuwaili EHA, Hussin AM, Khalaf HH. Histomorphological evaluation of docetaxel effects on testes and epididymides in Wistar rats. Open Vet J. 2025; 15(3): 1140-1149. doi:10.5455/OVJ.2025.v15.i3.6

Web Style

Ashour MS, Hussein AA, Al-shuwaili EHA, Hussin AM, Khalaf HH. Histomorphological evaluation of docetaxel effects on testes and epididymides in Wistar rats. https://www.openveterinaryjournal.com/?mno=227690 [Access: April 06, 2025]. doi:10.5455/OVJ.2025.v15.i3.6

AMA (American Medical Association) Style

Ashour MS, Hussein AA, Al-shuwaili EHA, Hussin AM, Khalaf HH. Histomorphological evaluation of docetaxel effects on testes and epididymides in Wistar rats. Open Vet J. 2025; 15(3): 1140-1149. doi:10.5455/OVJ.2025.v15.i3.6


Vancouver/ICMJE Style

Ashour MS, Hussein AA, Al-shuwaili EHA, Hussin AM, Khalaf HH. Histomorphological evaluation of docetaxel effects on testes and epididymides in Wistar rats. Open Vet J. (2025), [cited April 06, 2025]; 15(3): 1140-1149. doi:10.5455/OVJ.2025.v15.i3.6


Harvard Style

Ashour, M. S., Hussein, . A. A., Al-shuwaili, . E. H. A., Hussin, . A. M. & Khalaf, . H. H. (2025) Histomorphological evaluation of docetaxel effects on testes and epididymides in Wistar rats. Open Vet J, 15 (3), 1140-1149. doi:10.5455/OVJ.2025.v15.i3.6


Turabian Style

Ashour, Muntadher Salman, Ashwaq Ahmed Hussein, Entekhab Hameed Abed Al-shuwaili, Amer M. Hussin, and Harith Humadi Khalaf. 2025. Histomorphological evaluation of docetaxel effects on testes and epididymides in Wistar rats. Open Veterinary Journal, 15 (3), 1140-1149. doi:10.5455/OVJ.2025.v15.i3.6


Chicago Style

Ashour, Muntadher Salman, Ashwaq Ahmed Hussein, Entekhab Hameed Abed Al-shuwaili, Amer M. Hussin, and Harith Humadi Khalaf. "Histomorphological evaluation of docetaxel effects on testes and epididymides in Wistar rats." Open Veterinary Journal 15 (2025), 1140-1149. doi:10.5455/OVJ.2025.v15.i3.6


MLA (The Modern Language Association) Style

Ashour, Muntadher Salman, Ashwaq Ahmed Hussein, Entekhab Hameed Abed Al-shuwaili, Amer M. Hussin, and Harith Humadi Khalaf. "Histomorphological evaluation of docetaxel effects on testes and epididymides in Wistar rats." Open Veterinary Journal 15.3 (2025), 1140-1149. Print. doi:10.5455/OVJ.2025.v15.i3.6


APA (American Psychological Association) Style

Ashour, M. S., Hussein, . A. A., Al-shuwaili, . E. H. A., Hussin, . A. M. & Khalaf, . H. H. (2025) Histomorphological evaluation of docetaxel effects on testes and epididymides in Wistar rats. Open Veterinary Journal, 15 (3), 1140-1149. doi:10.5455/OVJ.2025.v15.i3.6


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