Abstract
Background:
Continuous noise with high dB intensity and continuously can cause psychological stress in a person. Stress during pregnancy can have a negative impact on fetal development, this is due to narrowing of the placental artery and ends in the obstruction of the flow of nutrients and oxygen to the fetus. Increased cortisol levels during pregnancy stress will signal the placenta to reduce the production of progesterone and estradiol, and stimulate the secretion of prostaglandins that activate contractions.

Aim:
This study aims to determine the effect of nanocurcumin administration on pregnant mice induced to noise stress used 135dB disturbance stress for 40 minutes with a continuous pattern.

Methods:
This study used 25 female mice in 5 groups, K (-) with no treatment, K(+) with 135dB disturbance induction for 40 minutes with a continuous pattern, P1 given disturbance and nanocurcumin dose 14mg/kgBW, P2 given disturbance and nanocurcumin dose 21 mg/kgBW, and P3 given disturbance and nanocurcumin 24.5 mg/kgBW. SOD and progesterone testing using ELISA.

Results:
Data analysis using One Way Anova followed by LSD. The result of this study conducted, nanocurcumin dose of 24.5 mg/kgBW gave the most significant effect (P<0.05) in reducing SOD levels and restoring progesterone levels in mice that had disorders during pregnancy compared to doses of 14 mg/kgBW and 21 mg/kgBW.

Conclusion:
The conclusion of this study, an administration of nanocurcumin at a dose of 24.5 mg/kgBW was effective in reducing oxidative stress and increasing progesterone levels in mice that experienced stress due to disorders during pregnancy.

Key words: Mice, Nanocurcumin, Noise stress, SOD, Progesterone