E-ISSN 2218-6050 | ISSN 2226-4485
 
2025, Vol: 15, Issue: 2
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Review Article


The mechanism underlying streptozotocin injection for the development of a nontransgenic Alzheimer’s disease animal model

Nurina Titisari, Hafandi Ahmad, Nurdiana Samsulrizal, Ahmad Fauzi, Intan Shameha Abdul Razak.


Abstract
Streptozotocin (STZ) is a widely used chemical agent in biomedical research. It is primarily known for its ability to induce high blood glucose levels in animal models by selectively destroying pancreatic beta cells. Nonetheless, many studies have also used STZ to generate animal models of diabetic complications, such as Alzheimer’s disease (AD) animal models. Streptozotocin induction promotes hyperglycemia, which activates numerous mechanism pathways that result in the production of pathogenic AD characteristics, including beta-amyloid accumulation and neurofibrillary tangles. Numerous theories exist to elucidate the mechanisms underlying diabetes and AD; however, studies on the potential of an animal model of STZ-induced AD remain limited. Thus, this review summarizes the pathogenesis associated with STZ exposure, particularly in AD animal model studies related to diabetes. More specifically, this study will discuss the relationship between increased blood glucose levels after STZ injection and the process of beta-amyloid formation and insulin dysfunction in the brain.

Key words: Beta-amyloid, Brain, Hyperglycemia, Neuron, Tau protein


 
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How to Cite this Article
Pubmed Style

Titisari N, Ahmad H, Samsulrizal N, Fauzi A, Razak ISA. The mechanism underlying streptozotocin injection for the development of a nontransgenic Alzheimer’s disease animal model. Open Vet J. 2025; 15(2): 594-600. doi:10.5455/OVJ.2025.v15.i2.8

Web Style

Titisari N, Ahmad H, Samsulrizal N, Fauzi A, Razak ISA. The mechanism underlying streptozotocin injection for the development of a nontransgenic Alzheimer’s disease animal model. https://www.openveterinaryjournal.com/?mno=231126 [Access: March 08, 2025]. doi:10.5455/OVJ.2025.v15.i2.8

AMA (American Medical Association) Style

Titisari N, Ahmad H, Samsulrizal N, Fauzi A, Razak ISA. The mechanism underlying streptozotocin injection for the development of a nontransgenic Alzheimer’s disease animal model. Open Vet J. 2025; 15(2): 594-600. doi:10.5455/OVJ.2025.v15.i2.8


Vancouver/ICMJE Style

Titisari N, Ahmad H, Samsulrizal N, Fauzi A, Razak ISA. The mechanism underlying streptozotocin injection for the development of a nontransgenic Alzheimer’s disease animal model. Open Vet J. (2025), [cited March 08, 2025]; 15(2): 594-600. doi:10.5455/OVJ.2025.v15.i2.8


Harvard Style

Titisari, N., Ahmad, . H., Samsulrizal, . N., Fauzi, . A. & Razak, . I. S. A. (2025) The mechanism underlying streptozotocin injection for the development of a nontransgenic Alzheimer’s disease animal model. Open Vet J, 15 (2), 594-600. doi:10.5455/OVJ.2025.v15.i2.8


Turabian Style

Titisari, Nurina, Hafandi Ahmad, Nurdiana Samsulrizal, Ahmad Fauzi, and Intan Shameha Abdul Razak. 2025. The mechanism underlying streptozotocin injection for the development of a nontransgenic Alzheimer’s disease animal model. Open Veterinary Journal, 15 (2), 594-600. doi:10.5455/OVJ.2025.v15.i2.8


Chicago Style

Titisari, Nurina, Hafandi Ahmad, Nurdiana Samsulrizal, Ahmad Fauzi, and Intan Shameha Abdul Razak. "The mechanism underlying streptozotocin injection for the development of a nontransgenic Alzheimer’s disease animal model." Open Veterinary Journal 15 (2025), 594-600. doi:10.5455/OVJ.2025.v15.i2.8


MLA (The Modern Language Association) Style

Titisari, Nurina, Hafandi Ahmad, Nurdiana Samsulrizal, Ahmad Fauzi, and Intan Shameha Abdul Razak. "The mechanism underlying streptozotocin injection for the development of a nontransgenic Alzheimer’s disease animal model." Open Veterinary Journal 15.2 (2025), 594-600. Print. doi:10.5455/OVJ.2025.v15.i2.8


APA (American Psychological Association) Style

Titisari, N., Ahmad, . H., Samsulrizal, . N., Fauzi, . A. & Razak, . I. S. A. (2025) The mechanism underlying streptozotocin injection for the development of a nontransgenic Alzheimer’s disease animal model. Open Veterinary Journal, 15 (2), 594-600. doi:10.5455/OVJ.2025.v15.i2.8


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