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Research Article


Effect of cinnamon oil (Cinnamomum burmannii) on the histological kidney of male diabetic rats (Rattus norvegicus)

Budiastuti Budiastuti, Naomi Lan Noviana Thesia, Hani Plumeriastuti, Mustofa Helmi Effendi, Emmanuel Nnabuike Ugbo, Aswin Rafif Khairullah, Ikechukwu Benjamin Moses, Katty Hendriana Priscilia Riwu, Riza Zainuddin Ahmad, Sheila Marty Yanestria, Wasito Wasito, Bima Putra Pratama, Mo Awwanah, Agung Prasetyo.


Abstract
Background:
Chronic systemic disease known as diabetes mellitus (DM) is defined by elevated blood glucose levels and problems with fat, carbohydrate, and protein metabolism. In Indonesia, the cinnamon species found include Cinnamomum burmannii, which also has hypoglycemic activity. The primary antioxidant chemicals found in Cinnamomum burmanii bark extract are polyphenols, which include tannins and flavonoids.

Aim:
The antidiabetic activity of cinnamon essential oil (Cinnamomum burmannii) against streptozotocin (STZ) was examined in this study.

Methods:
STZ (45 mg/kgBW) was administered intraperitoneally as a single dose. Twenty male rats were employed in this investigation. The rats were divided into five groups: treatment 1 (P1) was administered with streptozotocin and provided with 100 mg/kgBW; treatment 2 (P2) was administered with streptozotocin and provided with 200 mg/kgBW; and treatment 3 (P3) was administered with streptozotocin and provided with 400 mg/kgBW. The negative control group (K-) was not treated with streptozotocin and was treated with 1% Tween 80. For 14 days, the medication was administered daily.

Results:
The essential oil of cinnamon may lessen glomerulosclerosis, tubular necrosis, tubular degeneration, and glomerular necrosis. The kidney P3 treatment (400 mg/kgBW) produced negligible effects.

Conclusion:
It is possible to create cinnamon essential oil as an herbal antidiabetic medication by lowering the degree of kidney cell damage.

Key words: Cinnamomum burmannii, Essential oil, Kidney, Streptozotocin, Antidiabetic


 
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How to Cite this Article
Pubmed Style

Budiastuti B, Thesia NLN, Plumeriastuti H, Effendi MH, Ugbo EN, Khairullah AR, Moses IB, Riwu KHP, Ahmad RZ, Yanestria SM, Wasito W, Pratama BP, Awwanah M, Prasetyo A. Effect of cinnamon oil (Cinnamomum burmannii) on the histological kidney of male diabetic rats (Rattus norvegicus). Open Vet J. 2025; 15(2): 923-930. doi:10.5455/OVJ.2025.v15.i2.41

Web Style

Budiastuti B, Thesia NLN, Plumeriastuti H, Effendi MH, Ugbo EN, Khairullah AR, Moses IB, Riwu KHP, Ahmad RZ, Yanestria SM, Wasito W, Pratama BP, Awwanah M, Prasetyo A. Effect of cinnamon oil (Cinnamomum burmannii) on the histological kidney of male diabetic rats (Rattus norvegicus). https://www.openveterinaryjournal.com/?mno=234043 [Access: March 12, 2025]. doi:10.5455/OVJ.2025.v15.i2.41

AMA (American Medical Association) Style

Budiastuti B, Thesia NLN, Plumeriastuti H, Effendi MH, Ugbo EN, Khairullah AR, Moses IB, Riwu KHP, Ahmad RZ, Yanestria SM, Wasito W, Pratama BP, Awwanah M, Prasetyo A. Effect of cinnamon oil (Cinnamomum burmannii) on the histological kidney of male diabetic rats (Rattus norvegicus). Open Vet J. 2025; 15(2): 923-930. doi:10.5455/OVJ.2025.v15.i2.41


Vancouver/ICMJE Style

Budiastuti B, Thesia NLN, Plumeriastuti H, Effendi MH, Ugbo EN, Khairullah AR, Moses IB, Riwu KHP, Ahmad RZ, Yanestria SM, Wasito W, Pratama BP, Awwanah M, Prasetyo A. Effect of cinnamon oil (Cinnamomum burmannii) on the histological kidney of male diabetic rats (Rattus norvegicus). Open Vet J. (2025), [cited March 12, 2025]; 15(2): 923-930. doi:10.5455/OVJ.2025.v15.i2.41


Harvard Style

Budiastuti, B., Thesia, . N. L. N., Plumeriastuti, . H., Effendi, . M. H., Ugbo, . E. N., Khairullah, . A. R., Moses, . I. B., Riwu, . K. H. P., Ahmad, . R. Z., Yanestria, . S. M., Wasito, . W., Pratama, . B. P., Awwanah, . M. & Prasetyo, . A. (2025) Effect of cinnamon oil (Cinnamomum burmannii) on the histological kidney of male diabetic rats (Rattus norvegicus). Open Vet J, 15 (2), 923-930. doi:10.5455/OVJ.2025.v15.i2.41


Turabian Style

Budiastuti, Budiastuti, Naomi Lan Noviana Thesia, Hani Plumeriastuti, Mustofa Helmi Effendi, Emmanuel Nnabuike Ugbo, Aswin Rafif Khairullah, Ikechukwu Benjamin Moses, Katty Hendriana Priscilia Riwu, Riza Zainuddin Ahmad, Sheila Marty Yanestria, Wasito Wasito, Bima Putra Pratama, Mo Awwanah, and Agung Prasetyo. 2025. Effect of cinnamon oil (Cinnamomum burmannii) on the histological kidney of male diabetic rats (Rattus norvegicus). Open Veterinary Journal, 15 (2), 923-930. doi:10.5455/OVJ.2025.v15.i2.41


Chicago Style

Budiastuti, Budiastuti, Naomi Lan Noviana Thesia, Hani Plumeriastuti, Mustofa Helmi Effendi, Emmanuel Nnabuike Ugbo, Aswin Rafif Khairullah, Ikechukwu Benjamin Moses, Katty Hendriana Priscilia Riwu, Riza Zainuddin Ahmad, Sheila Marty Yanestria, Wasito Wasito, Bima Putra Pratama, Mo Awwanah, and Agung Prasetyo. "Effect of cinnamon oil (Cinnamomum burmannii) on the histological kidney of male diabetic rats (Rattus norvegicus)." Open Veterinary Journal 15 (2025), 923-930. doi:10.5455/OVJ.2025.v15.i2.41


MLA (The Modern Language Association) Style

Budiastuti, Budiastuti, Naomi Lan Noviana Thesia, Hani Plumeriastuti, Mustofa Helmi Effendi, Emmanuel Nnabuike Ugbo, Aswin Rafif Khairullah, Ikechukwu Benjamin Moses, Katty Hendriana Priscilia Riwu, Riza Zainuddin Ahmad, Sheila Marty Yanestria, Wasito Wasito, Bima Putra Pratama, Mo Awwanah, and Agung Prasetyo. "Effect of cinnamon oil (Cinnamomum burmannii) on the histological kidney of male diabetic rats (Rattus norvegicus)." Open Veterinary Journal 15.2 (2025), 923-930. Print. doi:10.5455/OVJ.2025.v15.i2.41


APA (American Psychological Association) Style

Budiastuti, B., Thesia, . N. L. N., Plumeriastuti, . H., Effendi, . M. H., Ugbo, . E. N., Khairullah, . A. R., Moses, . I. B., Riwu, . K. H. P., Ahmad, . R. Z., Yanestria, . S. M., Wasito, . W., Pratama, . B. P., Awwanah, . M. & Prasetyo, . A. (2025) Effect of cinnamon oil (Cinnamomum burmannii) on the histological kidney of male diabetic rats (Rattus norvegicus). Open Veterinary Journal, 15 (2), 923-930. doi:10.5455/OVJ.2025.v15.i2.41


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