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2026, Vol: 16, Issue: 6
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Research Article


Effectiveness effects of Ulva lactuca ethanol extract on estradiol levels, estrus cycle, and endometrial thickness in MSG-induced female rats

Luh Ari Arini, Luh Citrarasmi Dara Mestika.


Abstract
Background:
Excessive consumption of monosodium glutamate (MSG), a common food flavor enhancer, has been reported to adversely affect the female reproductive system. Therefore, to overcome the negative effects of consuming MSG which causes an oxidant effect, this can be overcome by consuming foods that contain sources of antioxidants.

Aim:
This study aimed to analyse the effect of Ulva lactuca ethanol extract on the estradiol hormone levels, estrus cycle and endometrial thickness in female rats exposed to MSG.

Methods:
Thirty adult female Wistar rats were divided into five groups: normal control, MSG-induced control, and three Ulva lactuca treatment groups (100, 200, and 400 mg/kgBW). Estradiol levels, endometrial thickness, and estrus cycle phases were assessed.

Results:
Administration of Ulva lactuca extract significantly improved estradiol levels (p=0.011), endometrial thickness (p=0.016), and estrus cycle regularity (p=0.005) compared to the MSG-induced group.

Conclusion:
Ulva lactuca ethanol extract showed potential in mitigating MSG-induced toxicity, supporting its use in preserving female reproductive health.

Key words: Endometrial, Estradiol hormone, Estrus Cycle, Monosodium Glutamate, Ulva Lactuca.


 
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How to Cite this Article
Pubmed Style

Arini LA, Mestika LCD. Effectiveness effects of Ulva lactuca ethanol extract on estradiol levels, estrus cycle, and endometrial thickness in MSG-induced female rats. Open Vet. J.. 2025; 15(10): 5221-5229. doi:10.5455/OVJ.2025.v15.i10.38

Web Style

Arini LA, Mestika LCD. Effectiveness effects of Ulva lactuca ethanol extract on estradiol levels, estrus cycle, and endometrial thickness in MSG-induced female rats. https://www.openveterinaryjournal.com/?mno=249709 [Access: June 22, 2026]. doi:10.5455/OVJ.2025.v15.i10.38

AMA (American Medical Association) Style

Arini LA, Mestika LCD. Effectiveness effects of Ulva lactuca ethanol extract on estradiol levels, estrus cycle, and endometrial thickness in MSG-induced female rats. Open Vet. J.. 2025; 15(10): 5221-5229. doi:10.5455/OVJ.2025.v15.i10.38


Vancouver/ICMJE Style

Arini LA, Mestika LCD. Effectiveness effects of Ulva lactuca ethanol extract on estradiol levels, estrus cycle, and endometrial thickness in MSG-induced female rats. Open Vet. J.. (2025), [cited June 22, 2026]; 15(10): 5221-5229. doi:10.5455/OVJ.2025.v15.i10.38


Harvard Style

Arini, L. A. & Mestika, . L. C. D. (2025) Effectiveness effects of Ulva lactuca ethanol extract on estradiol levels, estrus cycle, and endometrial thickness in MSG-induced female rats. Open Vet. J., 15 (10), 5221-5229. doi:10.5455/OVJ.2025.v15.i10.38


Turabian Style

Arini, Luh Ari, and Luh Citrarasmi Dara Mestika. 2025. Effectiveness effects of Ulva lactuca ethanol extract on estradiol levels, estrus cycle, and endometrial thickness in MSG-induced female rats. Open Veterinary Journal, 15 (10), 5221-5229. doi:10.5455/OVJ.2025.v15.i10.38


Chicago Style

Arini, Luh Ari, and Luh Citrarasmi Dara Mestika. "Effectiveness effects of Ulva lactuca ethanol extract on estradiol levels, estrus cycle, and endometrial thickness in MSG-induced female rats." Open Veterinary Journal 15 (2025), 5221-5229. doi:10.5455/OVJ.2025.v15.i10.38


MLA (The Modern Language Association) Style

Arini, Luh Ari, and Luh Citrarasmi Dara Mestika. "Effectiveness effects of Ulva lactuca ethanol extract on estradiol levels, estrus cycle, and endometrial thickness in MSG-induced female rats." Open Veterinary Journal 15.10 (2025), 5221-5229. Print. doi:10.5455/OVJ.2025.v15.i10.38


APA (American Psychological Association) Style

Arini, L. A. & Mestika, . L. C. D. (2025) Effectiveness effects of Ulva lactuca ethanol extract on estradiol levels, estrus cycle, and endometrial thickness in MSG-induced female rats. Open Veterinary Journal, 15 (10), 5221-5229. doi:10.5455/OVJ.2025.v15.i10.38


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