E-ISSN 2218-6050 | ISSN 2226-4485
 
2025, Vol: 15, Issue: 8
15 / 8Current Issue ArchiveAims and ScopeAbstracting & IndexingMost Accessed ArticlesMost Downloaded ArticlesMost Cited Articles
Required files to be uploaded

OVJ Manuscript Submissio Form

Research Article


Therapeutic potential of L-Carnitine in improving adenine-induced hematological abnormalities in rats: A preclinical pharmacological study

Waleed Khaled Y. Albahadly, Mohammed Jasim Jawad, Mohammed Ibrahim Rasool, Haider Falih Shamikhal-saedi, Asia Ali Hamza.


Abstract
Background:
Adenine is a naturally occurring purine essential for life, but its excess intake can cause metabolic disturbances leading to cardiovascular complications, renal stones, gout, fatigue, and anemia.

Aim:
This study aimed to investigate the potential hematological protective effects of L-Carnitine in rats subjected to adenine-induced toxicity.

Methods:
Twenty-four adult male Wistar rats were randomly assigned to four groups (n = 6). Group 1 received 3 ml of normal saline orally. Group 2 received 100 mg/kg of adenine orally. Group 3 received oral administration of both adenine (100 mg/kg) and L-Carnitine (750 mg/kg). Group 4 received oral L-Carnitine (750 mg/kg) for 30 days. The hematological parameters were assessed using an automated hematology analyzer.

Results:
Rats treated with adenine alone showed a significant reduction in red blood cells, hemoglobin, packed cell volume, and platelet counts and a marked increase in white blood cell levels (p < 0.05). Co-administration of L-Carnitine significantly ameliorated these hematological alterations.

Conclusion:
L-Carnitine exhibited a hematoprotective effect against adenine-induced toxicity, highlighting its potential therapeutic role in managing metabolic disturbances associated with purine overload.

Key words: L-Carnitine, Hematology, Adenine


 
ARTICLE TOOLS
Abstract
PDF Fulltext
How to cite this articleHow to cite this article
Citation Tools
Related Records
 Articles by Waleed Khaled Y. Albahadly
Articles by Mohammed Jasim Jawad
Articles by Mohammed Ibrahim Rasool
Articles by Haider Falih ShamikhAl-Saedi
Articles by Asia Ali Hamza
on Google
on Google Scholar


How to Cite this Article
Pubmed Style

Albahadly WKY, Jawad MJ, Rasool MI, Shamikhal-saedi HF, Hamza AA. Therapeutic potential of L-Carnitine in improving adenine-induced hematological abnormalities in rats: A preclinical pharmacological study. Open Vet. J.. 2025; 15(8): 3848-3853. doi:10.5455/OVJ.2025.v15.i8.50

Web Style

Albahadly WKY, Jawad MJ, Rasool MI, Shamikhal-saedi HF, Hamza AA. Therapeutic potential of L-Carnitine in improving adenine-induced hematological abnormalities in rats: A preclinical pharmacological study. https://www.openveterinaryjournal.com/?mno=251149 [Access: September 01, 2025]. doi:10.5455/OVJ.2025.v15.i8.50

AMA (American Medical Association) Style

Albahadly WKY, Jawad MJ, Rasool MI, Shamikhal-saedi HF, Hamza AA. Therapeutic potential of L-Carnitine in improving adenine-induced hematological abnormalities in rats: A preclinical pharmacological study. Open Vet. J.. 2025; 15(8): 3848-3853. doi:10.5455/OVJ.2025.v15.i8.50


Vancouver/ICMJE Style

Albahadly WKY, Jawad MJ, Rasool MI, Shamikhal-saedi HF, Hamza AA. Therapeutic potential of L-Carnitine in improving adenine-induced hematological abnormalities in rats: A preclinical pharmacological study. Open Vet. J.. (2025), [cited September 01, 2025]; 15(8): 3848-3853. doi:10.5455/OVJ.2025.v15.i8.50


Harvard Style

Albahadly, W. K. Y., Jawad, . M. J., Rasool, . M. I., Shamikhal-saedi, . H. F. & Hamza, . A. A. (2025) Therapeutic potential of L-Carnitine in improving adenine-induced hematological abnormalities in rats: A preclinical pharmacological study. Open Vet. J., 15 (8), 3848-3853. doi:10.5455/OVJ.2025.v15.i8.50


Turabian Style

Albahadly, Waleed Khaled Y., Mohammed Jasim Jawad, Mohammed Ibrahim Rasool, Haider Falih Shamikhal-saedi, and Asia Ali Hamza. 2025. Therapeutic potential of L-Carnitine in improving adenine-induced hematological abnormalities in rats: A preclinical pharmacological study. Open Veterinary Journal, 15 (8), 3848-3853. doi:10.5455/OVJ.2025.v15.i8.50


Chicago Style

Albahadly, Waleed Khaled Y., Mohammed Jasim Jawad, Mohammed Ibrahim Rasool, Haider Falih Shamikhal-saedi, and Asia Ali Hamza. "Therapeutic potential of L-Carnitine in improving adenine-induced hematological abnormalities in rats: A preclinical pharmacological study." Open Veterinary Journal 15 (2025), 3848-3853. doi:10.5455/OVJ.2025.v15.i8.50


MLA (The Modern Language Association) Style

Albahadly, Waleed Khaled Y., Mohammed Jasim Jawad, Mohammed Ibrahim Rasool, Haider Falih Shamikhal-saedi, and Asia Ali Hamza. "Therapeutic potential of L-Carnitine in improving adenine-induced hematological abnormalities in rats: A preclinical pharmacological study." Open Veterinary Journal 15.8 (2025), 3848-3853. Print. doi:10.5455/OVJ.2025.v15.i8.50


APA (American Psychological Association) Style

Albahadly, W. K. Y., Jawad, . M. J., Rasool, . M. I., Shamikhal-saedi, . H. F. & Hamza, . A. A. (2025) Therapeutic potential of L-Carnitine in improving adenine-induced hematological abnormalities in rats: A preclinical pharmacological study. Open Veterinary Journal, 15 (8), 3848-3853. doi:10.5455/OVJ.2025.v15.i8.50


Author LoginReviewer LoginAbout PublisherPublication Ethics and Publication Malpractice StatementConflict of Interest PolicyPlagiarism PolicyTerms of UseLicense InformationCopyright Information

About Open Veterinary Journal

Open Veterinary Journal provides a fast track coupled with high quality peer review process for original research articles, review articles, short communi ... Read more.



For best results, please use Internet Explorer or Google Chrome.

Contact Information

All correspondence should be addressed to:

Prof. Ibrahim Eldaghayes: Owner, Founder and Editor-in-Chief

Open Veterinary Journal


Faculty of Veterinary Medicine, University of Tripoli

P.O. Box 13662, Tripoli, Libya

and


Eldaghayes Publisher

www.eldaghayes.com 

Email: ibrahim.eldaghayes@vetmed.edu.ly