The ameliorative effects of Myrmecodia sp. as an antibiotic growth promoter in broiler chicken with avian pathogenic Escherichia coli infection

Ertika Fitri Lisnanti; Widya Paramita Lokapirnasari; Mohammad Anam Al-Arif; Eka Pramyrtha Hestianah; Sri Hidanah; Ikechukwu Benjamin Moses; M. Gandul Atik Yuliani; Zein Ahmad Baihaqi; Fidi Nur Aini Eka Puji Dameanti; Aswin Rafif Khairullah; Viski Fitri Hendrawan; Saifur Rehman

doi:10.5455/OVJ.2025.v15.i11.41

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Open Vet. J.. 2025; 15(11): 5858-5871

doi: 10.5455/OVJ.2025.v15.i11.41

The ameliorative effects of Myrmecodia sp. as an antibiotic growth promoter in broiler chicken with avian pathogenic Escherichia coli infection

Ertika Fitri Lisnanti, Widya Paramita Lokapirnasari, Mohammad Anam Al-arif, Eka Pramyrtha Hestianah, Sri Hidanah, Ikechukwu Benjamin Moses, M. Gandul Atik Yuliani, Zein Ahmad Baihaqi, Fidi Nur Aini Eka Puji Dameanti, Aswin Rafif Khairullah, Viski Fitri Hendrawan, Saifur Rehman.

Abstract
Background:
Broiler livestock supports the fulfillment of animal protein in a country where the meat price is affordable for the wider population. However, its progress faces numerous challenges, with colibacillosis, induced by APEC, being a significant concern due to its detrimental impact on production levels, as evidenced by elevated morbidity and mortality rates. Exploring natural antibacterial substances, such as ant nest extracts, presents promising avenues for combating APEC.

Aim:
This study investigated the potential of Myrmecodia sp. extract as a natural feed additive to improve performance and immune responses in APEC-challenged broiler chickens.

Methods:
The effects of varying concentrations of Myrmecodia extract (15% and 30%) at 0.1% concentration and infusions (1% and 2%) were evaluated against a zinc bacitracin control using a completely randomized design with seven treatments and four replications. Growth performance indicators, including feed intake, total body weight, feed conversion ratio (FCR), feed efficiency, and immune markers (leukocytes, lymphocytes, monocytes, granulocytes, erythrocytes, hemoglobin, hematocrit, platelets, malondialdehyde, and superoxide dismutase levels) were measured.

Results:
Results showed that 15% extract improved FCR by 1.47%, while 30% extract further boosted feed intake and weight gain. Infusion treatments also demonstrated positive effects: the 20 ml infusion improved FCR and stabilized leukocyte and platelet counts, while the 10 ml infusion enhanced overall performance, reduced blood urea nitrogen (BUN) levels, and positively impacted lipid profiles.

Conclusion:
Myrmecodia sp. has the potential to serve as a natural alternative to antibiotic growth promoters in broiler production. However, these results should be interpreted with caution, and further confirmation is required.

Key words: Myrmecodia sp.; Broiler; Feed additive; Antibiotic growth promoter.

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How to Cite this Article

Pubmed Style

Lisnanti EF, Lokapirnasari WP, Al-arif MA, Hestianah EP, Hidanah S, Moses IB, Yuliani MGA, Baihaqi ZA, , Khairullah AR, Hendrawan VF, Rehman S. The ameliorative effects of Myrmecodia sp. as an antibiotic growth promoter in broiler chicken with avian pathogenic Escherichia coli infection. doi:10.5455/OVJ.2025.v15.i11.41

Web Style

Lisnanti EF, Lokapirnasari WP, Al-arif MA, Hestianah EP, Hidanah S, Moses IB, Yuliani MGA, Baihaqi ZA, , Khairullah AR, Hendrawan VF, Rehman S. The ameliorative effects of Myrmecodia sp. as an antibiotic growth promoter in broiler chicken with avian pathogenic Escherichia coli infection. https://www.openveterinaryjournal.com/?mno=253433 [Access: November 30, 2025]. doi:10.5455/OVJ.2025.v15.i11.41

AMA (American Medical Association) Style

Lisnanti EF, Lokapirnasari WP, Al-arif MA, Hestianah EP, Hidanah S, Moses IB, Yuliani MGA, Baihaqi ZA, , Khairullah AR, Hendrawan VF, Rehman S. The ameliorative effects of Myrmecodia sp. as an antibiotic growth promoter in broiler chicken with avian pathogenic Escherichia coli infection. doi:10.5455/OVJ.2025.v15.i11.41

Vancouver/ICMJE Style

Harvard Style

Lisnanti, E. F., Lokapirnasari, . W. P., Al-arif, . M. A., Hestianah, . E. P., Hidanah, . S., Moses, . I. B., Yuliani, . M. G. A., Baihaqi, . Z. A., , Khairullah, . A. R., Hendrawan, . V. F. & Rehman, . S. (2025) The ameliorative effects of Myrmecodia sp. as an antibiotic growth promoter in broiler chicken with avian pathogenic Escherichia coli infection. doi:10.5455/OVJ.2025.v15.i11.41

Turabian Style

Lisnanti, Ertika Fitri, Widya Paramita Lokapirnasari, Mohammad Anam Al-arif, Eka Pramyrtha Hestianah, Sri Hidanah, Ikechukwu Benjamin Moses, M. Gandul Atik Yuliani, Zein Ahmad Baihaqi, Fidi Nur Aini Eka Puji Dameanti, Aswin Rafif Khairullah, Viski Fitri Hendrawan, and Saifur Rehman. 2025. The ameliorative effects of Myrmecodia sp. as an antibiotic growth promoter in broiler chicken with avian pathogenic Escherichia coli infection. doi:10.5455/OVJ.2025.v15.i11.41

Chicago Style

Lisnanti, Ertika Fitri, Widya Paramita Lokapirnasari, Mohammad Anam Al-arif, Eka Pramyrtha Hestianah, Sri Hidanah, Ikechukwu Benjamin Moses, M. Gandul Atik Yuliani, Zein Ahmad Baihaqi, Fidi Nur Aini Eka Puji Dameanti, Aswin Rafif Khairullah, Viski Fitri Hendrawan, and Saifur Rehman. "The ameliorative effects of Myrmecodia sp. as an antibiotic growth promoter in broiler chicken with avian pathogenic Escherichia coli infection." doi:10.5455/OVJ.2025.v15.i11.41

MLA (The Modern Language Association) Style

Lisnanti, Ertika Fitri, Widya Paramita Lokapirnasari, Mohammad Anam Al-arif, Eka Pramyrtha Hestianah, Sri Hidanah, Ikechukwu Benjamin Moses, M. Gandul Atik Yuliani, Zein Ahmad Baihaqi, Fidi Nur Aini Eka Puji Dameanti, Aswin Rafif Khairullah, Viski Fitri Hendrawan, and Saifur Rehman. "The ameliorative effects of Myrmecodia sp. as an antibiotic growth promoter in broiler chicken with avian pathogenic Escherichia coli infection." doi:10.5455/OVJ.2025.v15.i11.41

APA (American Psychological Association) Style

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