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2025, Vol: 15, Issue: 3
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Case Report


Isolated limb perfusion electrochemotherapy for the treatment of an advanced squamous cell carcinoma of the hoof in a mare

Enrico Pierluigi Spugnini, Carlo Bolaffio, Licia Scacco, Alfonso Baldi.


Cited By:15

Abstract
A twenty-year-old female saddle horse was referred for evaluation of a seven month, non-healing erosive lesion of the right hind hoof with proliferation and bleeding of the underlying soft tissues. This lesion had been twice surgically treated as a canker but rapidly recurred. Histological examination of the second excision revealed a well-differentiated squamous cell carcinoma. At presentation, the horse was mildly depressed, lame and partially non-weight-bearing on the right hind leg, which exhibited a 10 x 10 cm erosive and proliferative lesion remodeling the hoof. After completing staging procedures, the lesion was approached with surgery and intraoperative electrochemotherapy (ECT) administration of bleomycin in isolated limb perfusion. A second session of surgery and ECT was performed one month later, followed by three additional monthly sessions of ECT. During periodic recheck, the mare showed continuous improvement. One year after presentation, the mare was in complete remission and her gait markedly improved. ECT was well-tolerated and resulted in improved local control of a tumor in a challenging anatomical district.

Key words: bleomycin, electrochemotherapy, equine, hoof, squamous cell carcinoma


 
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How to Cite this Article
Pubmed Style

Spugnini EP, Bolaffio C, Scacco L, Baldi A. Isolated limb perfusion electrochemotherapy for the treatment of an advanced squamous cell carcinoma of the hoof in a mare. Open Vet J. 2017; 7(2): 192-196. doi:10.4314/ovj.v7i2.18

Web Style

Spugnini EP, Bolaffio C, Scacco L, Baldi A. Isolated limb perfusion electrochemotherapy for the treatment of an advanced squamous cell carcinoma of the hoof in a mare. https://www.openveterinaryjournal.com/?mno=257958 [Access: April 14, 2025]. doi:10.4314/ovj.v7i2.18

AMA (American Medical Association) Style

Spugnini EP, Bolaffio C, Scacco L, Baldi A. Isolated limb perfusion electrochemotherapy for the treatment of an advanced squamous cell carcinoma of the hoof in a mare. Open Vet J. 2017; 7(2): 192-196. doi:10.4314/ovj.v7i2.18


Vancouver/ICMJE Style

Spugnini EP, Bolaffio C, Scacco L, Baldi A. Isolated limb perfusion electrochemotherapy for the treatment of an advanced squamous cell carcinoma of the hoof in a mare. Open Vet J. (2017), [cited April 14, 2025]; 7(2): 192-196. doi:10.4314/ovj.v7i2.18


Harvard Style

Spugnini, E. P., Bolaffio, . C., Scacco, . L. & Baldi, . A. (2017) Isolated limb perfusion electrochemotherapy for the treatment of an advanced squamous cell carcinoma of the hoof in a mare. Open Vet J, 7 (2), 192-196. doi:10.4314/ovj.v7i2.18


Turabian Style

Spugnini, Enrico Pierluigi, Carlo Bolaffio, Licia Scacco, and Alfonso Baldi. 2017. Isolated limb perfusion electrochemotherapy for the treatment of an advanced squamous cell carcinoma of the hoof in a mare. Open Veterinary Journal, 7 (2), 192-196. doi:10.4314/ovj.v7i2.18


Chicago Style

Spugnini, Enrico Pierluigi, Carlo Bolaffio, Licia Scacco, and Alfonso Baldi. "Isolated limb perfusion electrochemotherapy for the treatment of an advanced squamous cell carcinoma of the hoof in a mare." Open Veterinary Journal 7 (2017), 192-196. doi:10.4314/ovj.v7i2.18


MLA (The Modern Language Association) Style

Spugnini, Enrico Pierluigi, Carlo Bolaffio, Licia Scacco, and Alfonso Baldi. "Isolated limb perfusion electrochemotherapy for the treatment of an advanced squamous cell carcinoma of the hoof in a mare." Open Veterinary Journal 7.2 (2017), 192-196. Print. doi:10.4314/ovj.v7i2.18


APA (American Psychological Association) Style

Spugnini, E. P., Bolaffio, . C., Scacco, . L. & Baldi, . A. (2017) Isolated limb perfusion electrochemotherapy for the treatment of an advanced squamous cell carcinoma of the hoof in a mare. Open Veterinary Journal, 7 (2), 192-196. doi:10.4314/ovj.v7i2.18


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