E-ISSN 2218-6050 | ISSN 2226-4485
 

Research Article 


The effect of giving 96% ethanol extract of dayak onion bulb on blood pressure reduction in a preclampsia mice model

Wita Asmalinda, Irwanto Irwanto, Budi Prasetyo.


Abstract
Background:
Early diagnosis and treatment of hypertension in preeclampsia are crucial to prevent complications that threaten both mother and fetus. Dayak onion bulbs contain active compounds that may be beneficial for treating hypertension during pregnancy.

Aim:
This study aimed to evaluate the effect of 96% ethanol extract of Dayak onion bulbs on reducing blood pressure in mice with experimentally induced preeclampsia.

Methods:
Thirty female rats were divided into five groups: two control groups and three treatment groups receiving ethanol extract of Dayak onion bulbs at doses of 90 mg/kg BW, 100 mg/kg BW, and 125 mg/kg BW, respectively. The study was conducted across three laboratories from October 1, 2024, to January 14, 2025.

Results:
The findings demonstrated that the 96% ethanol extract of Dayak onion bulbs has potential antihypertensive effects in a preeclampsia model, particularly in reducing systolic blood pressure. However, its effects on diastolic blood pressure require further investigation.

Conclusion:
The 96% ethanol extract of Dayak onion bulbs showed a significant antihypertensive effect on systolic blood pressure. Although there was a downward trend in diastolic blood pressure, not all reductions were statistically significant.

Key words: Blood pressure; Dayak onion bulbs; Preeclampsia model.


 
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How to Cite this Article
Pubmed Style

Asmalinda W, Irwanto I, Prasetyo B. The effect of giving 96% ethanol extract of dayak onion bulb on blood pressure reduction in a preclampsia mice model. doi:10.5455/OVJ.2025.v15.i11.36


Web Style

Asmalinda W, Irwanto I, Prasetyo B. The effect of giving 96% ethanol extract of dayak onion bulb on blood pressure reduction in a preclampsia mice model. https://www.openveterinaryjournal.com/?mno=260451 [Access: November 30, 2025]. doi:10.5455/OVJ.2025.v15.i11.36


AMA (American Medical Association) Style

Asmalinda W, Irwanto I, Prasetyo B. The effect of giving 96% ethanol extract of dayak onion bulb on blood pressure reduction in a preclampsia mice model. doi:10.5455/OVJ.2025.v15.i11.36



Vancouver/ICMJE Style

Asmalinda W, Irwanto I, Prasetyo B. The effect of giving 96% ethanol extract of dayak onion bulb on blood pressure reduction in a preclampsia mice model. doi:10.5455/OVJ.2025.v15.i11.36



Harvard Style

Asmalinda, W., Irwanto, . I. & Prasetyo, . B. (2025) The effect of giving 96% ethanol extract of dayak onion bulb on blood pressure reduction in a preclampsia mice model. doi:10.5455/OVJ.2025.v15.i11.36



Turabian Style

Asmalinda, Wita, Irwanto Irwanto, and Budi Prasetyo. 2025. The effect of giving 96% ethanol extract of dayak onion bulb on blood pressure reduction in a preclampsia mice model. doi:10.5455/OVJ.2025.v15.i11.36



Chicago Style

Asmalinda, Wita, Irwanto Irwanto, and Budi Prasetyo. "The effect of giving 96% ethanol extract of dayak onion bulb on blood pressure reduction in a preclampsia mice model." doi:10.5455/OVJ.2025.v15.i11.36



MLA (The Modern Language Association) Style

Asmalinda, Wita, Irwanto Irwanto, and Budi Prasetyo. "The effect of giving 96% ethanol extract of dayak onion bulb on blood pressure reduction in a preclampsia mice model." doi:10.5455/OVJ.2025.v15.i11.36



APA (American Psychological Association) Style

Asmalinda, W., Irwanto, . I. & Prasetyo, . B. (2025) The effect of giving 96% ethanol extract of dayak onion bulb on blood pressure reduction in a preclampsia mice model. doi:10.5455/OVJ.2025.v15.i11.36