E-ISSN 2218-6050 | ISSN 2226-4485
| - | | |
TGF-β1 serum concentrations and receptor expressions in the lens capsular of dogs with diabetes mellitus
Stephan Neumann1, *, Jens Linek2, Gerhard Loesenbeck3, Julia Schüttler1 And Sonja Gaedke1.
 | | Cited By:8 | | Abstract
Tissue fibrosis as complication of diabetes mellitus is known in humans. Because TGF-β1induces fibrosis and is
elevated in humans suffering from diabetes mellitus we measured this growth factor in serum of dogs with diabetes
mellitus and compared it with healthy dogs and those with fibrotic diseases. Further we measured the expression of
TGF-β1receptor on lens capsule to investigate possible association between diabetes mellitus and cataract associated
alterations. TGF-β1 was measured in serum of 12 dogs with diabetes mellitus, 20 healthy controls and 12 dogs with
fibrotic diseases. Dogs with diabetes mellitus and fibrotic diseases have significantly increased TGF-β1 serum
concentrations compared to healthy controls. Some dogs with diabetes mellitus showed increased expression of TGF-
β1 receptor in lens capsule. Based on our observations we can conclude that TGF-β1 elevation in dogs with diabetes
mellitus may induces complications of the disease and may participates on lens alteration. Key words: Cataracts, Diabetes mellitus, Dogs, TGF-β1.
| |
| |
