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2026, Vol: 16, Issue: 6
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Case Report


Clinical and pathological findings of metastatic hemangiosarcoma in a Doberman

Shahrzad Azizi, Setayesh Sadat Naseri, Mahdieh Rezaei, Reza Kheirandish, Mohammad Mehdi Oloumi, Saeed Hassanzadeh, Sina Delshad.


Abstract
Background:
Canine hemangiosarcoma (HSA) is a highly malignant tumor originating from endothelial cells that frequently affects the spleen with rapid metastatic spread. Although metastases commonly involve the lungs and liver, brain involvement is rare.

Case Description:
Splenic HSA with extensive metastasis in a 7-year-old male Doberman is described. The dog was referred with lethargy, anorexia, and walking incoordination. Radiographic and ultrasonographic examination confirmed liver and lung metastases. Necropsy revealed multiple dark-red nodules in the spleen, lungs, and central nervous system, including the cerebrum and cerebellum.

Conclusion:
In the histopathologic investigation, HSA was diagnosed. Irregular vascular channels lined the proliferative endothelial cells containing erythrocytes, and pleomorphism was observed. Because canine HSA is analogous to human angiosarcoma, further studies are needed to explore targeted therapies that could enhance survival in both species.

Key words: Dog; Hemangiosarcoma; Metastasis; Pathology.


 
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How to Cite this Article
Pubmed Style

Azizi S, Naseri SS, Rezaei M, Kheirandish R, Oloumi MM, Hassanzadeh S, Delshad S. Clinical and pathological findings of metastatic hemangiosarcoma in a Doberman. Open Vet. J.. 2026; 16(6): 3601-3605. doi:10.5455/OVJ.2026.v16.i6.32

Web Style

Azizi S, Naseri SS, Rezaei M, Kheirandish R, Oloumi MM, Hassanzadeh S, Delshad S. Clinical and pathological findings of metastatic hemangiosarcoma in a Doberman. https://www.openveterinaryjournal.com/?mno=309770 [Access: June 09, 2026]. doi:10.5455/OVJ.2026.v16.i6.32

AMA (American Medical Association) Style

Azizi S, Naseri SS, Rezaei M, Kheirandish R, Oloumi MM, Hassanzadeh S, Delshad S. Clinical and pathological findings of metastatic hemangiosarcoma in a Doberman. Open Vet. J.. 2026; 16(6): 3601-3605. doi:10.5455/OVJ.2026.v16.i6.32


Vancouver/ICMJE Style

Azizi S, Naseri SS, Rezaei M, Kheirandish R, Oloumi MM, Hassanzadeh S, Delshad S. Clinical and pathological findings of metastatic hemangiosarcoma in a Doberman. Open Vet. J.. (2026), [cited June 09, 2026]; 16(6): 3601-3605. doi:10.5455/OVJ.2026.v16.i6.32


Harvard Style

Azizi, S., Naseri, . S. S., Rezaei, . M., Kheirandish, . R., Oloumi, . M. M., Hassanzadeh, . S. & Delshad, . S. (2026) Clinical and pathological findings of metastatic hemangiosarcoma in a Doberman. Open Vet. J., 16 (6), 3601-3605. doi:10.5455/OVJ.2026.v16.i6.32


Turabian Style

Azizi, Shahrzad, Setayesh Sadat Naseri, Mahdieh Rezaei, Reza Kheirandish, Mohammad Mehdi Oloumi, Saeed Hassanzadeh, and Sina Delshad. 2026. Clinical and pathological findings of metastatic hemangiosarcoma in a Doberman. Open Veterinary Journal, 16 (6), 3601-3605. doi:10.5455/OVJ.2026.v16.i6.32


Chicago Style

Azizi, Shahrzad, Setayesh Sadat Naseri, Mahdieh Rezaei, Reza Kheirandish, Mohammad Mehdi Oloumi, Saeed Hassanzadeh, and Sina Delshad. "Clinical and pathological findings of metastatic hemangiosarcoma in a Doberman." Open Veterinary Journal 16 (2026), 3601-3605. doi:10.5455/OVJ.2026.v16.i6.32


MLA (The Modern Language Association) Style

Azizi, Shahrzad, Setayesh Sadat Naseri, Mahdieh Rezaei, Reza Kheirandish, Mohammad Mehdi Oloumi, Saeed Hassanzadeh, and Sina Delshad. "Clinical and pathological findings of metastatic hemangiosarcoma in a Doberman." Open Veterinary Journal 16.6 (2026), 3601-3605. Print. doi:10.5455/OVJ.2026.v16.i6.32


APA (American Psychological Association) Style

Azizi, S., Naseri, . S. S., Rezaei, . M., Kheirandish, . R., Oloumi, . M. M., Hassanzadeh, . S. & Delshad, . S. (2026) Clinical and pathological findings of metastatic hemangiosarcoma in a Doberman. Open Veterinary Journal, 16 (6), 3601-3605. doi:10.5455/OVJ.2026.v16.i6.32


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