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2024, Vol: 14, Issue: 10
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Original Article


Bilateral Asymptomatic Common Carotid Artery Stenosis (BACAS) Mouse Model for Stroke Research

Achmad Firdaus Sani, Widjiati Widjiati, Paulus Sugianto, Muhammad Hamdan, Jovian Philip Swatan.


Cited By:1

Abstract
Background: Asymptomatic carotid artery stenosis has become more prevalent worldwide and is often associated with a poor prognosis. Numerous guidelines highlighted surgical interventions as treatment for carotid artery stenosis, but only a few recommendations were made regarding non-surgical interventions due to its limited data.
Aims: This study aims to develop a mice model for research in non-surgical interventions of asymptomatic carotid artery stenosis.
Methods: Adult male Rattus Norvegicus, Wistar strain models with bilateral asymptomatic common carotid artery stenosis (BACAS) were created by ligating the common carotid artery with a 0.6 mm diameter needle and then removing the needle. The mice’s body weight, clinical signs and symptoms, and post-mortem brain analysis were compared between the sham-operated group and the BACAS group. Results: The mortality rate among BACAS group is 11.11%. There is no significant difference in mean body weight before surgery, after the observation period, and percentage of weight decrease between sham-operated and BACAS groups (p=0.710, 0.632, and 0.806, respectively). None of the surviving mice in this study exhibit signs of motor paralysis. Gross examination of the brain reveals no signs of infarction or hemorrhage.
Conclusion: We have established a novel BACAS mouse model which is cost-efficient, easy to produce, and with no significant alteration in body weight, clinical parameters, and brain morphology.

Key words: Animal models of disease, carotid arteries, mouse models, non-communicable disease, Scientific research


 
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How to Cite this Article
Pubmed Style

Sani AF, Widjiati W, Sugianto P, Hamdan M, Swatan JP, . Bilateral Asymptomatic Common Carotid Artery Stenosis (BACAS) Mouse Model for Stroke Research. Open Vet J. 2022; 12(4): 463-468. doi:10.5455/OVJ.2022.v12.i4.7

Web Style

Sani AF, Widjiati W, Sugianto P, Hamdan M, Swatan JP, . Bilateral Asymptomatic Common Carotid Artery Stenosis (BACAS) Mouse Model for Stroke Research. https://www.openveterinaryjournal.com/?mno=5523 [Access: November 08, 2024]. doi:10.5455/OVJ.2022.v12.i4.7

AMA (American Medical Association) Style

Sani AF, Widjiati W, Sugianto P, Hamdan M, Swatan JP, . Bilateral Asymptomatic Common Carotid Artery Stenosis (BACAS) Mouse Model for Stroke Research. Open Vet J. 2022; 12(4): 463-468. doi:10.5455/OVJ.2022.v12.i4.7


Vancouver/ICMJE Style

Sani AF, Widjiati W, Sugianto P, Hamdan M, Swatan JP, . Bilateral Asymptomatic Common Carotid Artery Stenosis (BACAS) Mouse Model for Stroke Research. Open Vet J. (2022), [cited November 08, 2024]; 12(4): 463-468. doi:10.5455/OVJ.2022.v12.i4.7


Harvard Style

Sani, A. F., Widjiati, W., Sugianto, P., Hamdan, M., Swatan, J. P. & (2022) Bilateral Asymptomatic Common Carotid Artery Stenosis (BACAS) Mouse Model for Stroke Research. Open Vet J, 12 (4), 463-468. doi:10.5455/OVJ.2022.v12.i4.7


Turabian Style

Sani, Achmad Firdaus, Widjiati Widjiati, Paulus Sugianto, Muhammad Hamdan, Jovian Philip Swatan, and . 2022. Bilateral Asymptomatic Common Carotid Artery Stenosis (BACAS) Mouse Model for Stroke Research. Open Veterinary Journal, 12 (4), 463-468. doi:10.5455/OVJ.2022.v12.i4.7


Chicago Style

Sani, Achmad Firdaus, Widjiati Widjiati, Paulus Sugianto, Muhammad Hamdan, Jovian Philip Swatan, and . "Bilateral Asymptomatic Common Carotid Artery Stenosis (BACAS) Mouse Model for Stroke Research." Open Veterinary Journal 12 (2022), 463-468. doi:10.5455/OVJ.2022.v12.i4.7


MLA (The Modern Language Association) Style

Sani, Achmad Firdaus, Widjiati Widjiati, Paulus Sugianto, Muhammad Hamdan, Jovian Philip Swatan, and . "Bilateral Asymptomatic Common Carotid Artery Stenosis (BACAS) Mouse Model for Stroke Research." Open Veterinary Journal 12.4 (2022), 463-468. Print. doi:10.5455/OVJ.2022.v12.i4.7


APA (American Psychological Association) Style

Sani, A. F., Widjiati, W., Sugianto, P., Hamdan, M., Swatan, J. P. & (2022) Bilateral Asymptomatic Common Carotid Artery Stenosis (BACAS) Mouse Model for Stroke Research. Open Veterinary Journal, 12 (4), 463-468. doi:10.5455/OVJ.2022.v12.i4.7


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