E-ISSN 2218-6050 | ISSN 2226-4485
 
2024, Vol: 14, Issue: 10
14 / 10Current Issue ArchiveAims and ScopeAbstracting & IndexingMost Accessed ArticlesMost Downloaded ArticlesMost Cited Articles
Required files to be uploaded

OVJ Manuscript Submission Form

Original Article


Prognostic role of ΔNp63 expression in canine transitional cell carcinoma of the urinary bladder

Tomohiro Nishimori, Kiwamu Hanazono, Kazuya Matsuda, Yoshio Kawamura, Tsuyoshi Kadosawa, Yoshifumi Endo, Tsuyoshi Uchide.


Cited By:1

Abstract
Background: Decreased p63 protein expression in canine transitional cell carcinoma (TCC) of the urinary bladder is associated with vascular invasion of the tumor, metastasis, and shortened survival. ΔNp63, an isoform of p63, is downregulated in high-grade invasive urothelial carcinoma in humans. However, the clinical significance of ΔNp63 expression in canine urinary bladder tumors is unknown. Therefore, it is important to investigate ΔNp63 expression patterns in TCC, the most common urinary bladder tumor in dogs.
Aim: This study aimed to evaluate the expression and role of ΔNp63 in canine TCC of the urinary bladder.
Methods: ΔNp63 expression was compared between the normal canine urinary bladder, polypoid cystitis, and TCC. The correlation of ΔNp63 expression with histopathological and clinical findings was further evaluated, and its usefulness as a prognostic factor was examined.
Results: We observed that ΔNp63 was highly expressed in the normal urinary bladder and polypoid cystitis in dogs, and its expression levels were low in TCC. Furthermore, low levels of ΔNp63 expression were associated with vascular invasion, metastasis, and shortened survival in dogs with TCC.
Conclusion: These results indicate that ΔNp63 expression could serve as a useful biomarker for invasion, metastasis, and prognosis of canine TCC of the urinary bladder.

Key words: metastasis, ΔNp63, survival, transitional cell carcinoma, urinary bladder


 
ARTICLE TOOLS
Abstract
PDF Fulltext
HTML Fulltext
How to cite this articleHow to cite this article
Citation Tools
Related Records
 Articles by Tomohiro Nishimori
Articles by Kiwamu Hanazono
Articles by Kazuya Matsuda
Articles by Yoshio Kawamura
Articles by Tsuyoshi Kadosawa
Articles by Yoshifumi Endo
Articles by Tsuyoshi Uchide
on Google
on Google Scholar


How to Cite this Article
Pubmed Style

Nishimori T, Hanazono K, Matsuda K, Kawamura Y, Kadosawa T, Endo Y, Uchide T. Prognostic role of ΔNp63 expression in canine transitional cell carcinoma of the urinary bladder. Open Vet J. 2021; 11(4): 700-706. doi:10.5455/OVJ.2021.v11.i4.22

Web Style

Nishimori T, Hanazono K, Matsuda K, Kawamura Y, Kadosawa T, Endo Y, Uchide T. Prognostic role of ΔNp63 expression in canine transitional cell carcinoma of the urinary bladder. https://www.openveterinaryjournal.com/?mno=86227 [Access: November 08, 2024]. doi:10.5455/OVJ.2021.v11.i4.22

AMA (American Medical Association) Style

Nishimori T, Hanazono K, Matsuda K, Kawamura Y, Kadosawa T, Endo Y, Uchide T. Prognostic role of ΔNp63 expression in canine transitional cell carcinoma of the urinary bladder. Open Vet J. 2021; 11(4): 700-706. doi:10.5455/OVJ.2021.v11.i4.22


Vancouver/ICMJE Style

Nishimori T, Hanazono K, Matsuda K, Kawamura Y, Kadosawa T, Endo Y, Uchide T. Prognostic role of ΔNp63 expression in canine transitional cell carcinoma of the urinary bladder. Open Vet J. (2021), [cited November 08, 2024]; 11(4): 700-706. doi:10.5455/OVJ.2021.v11.i4.22


Harvard Style

Nishimori, T., Hanazono, . K., Matsuda, . K., Kawamura, . Y., Kadosawa, . T., Endo, . Y. & Uchide, . T. (2021) Prognostic role of ΔNp63 expression in canine transitional cell carcinoma of the urinary bladder. Open Vet J, 11 (4), 700-706. doi:10.5455/OVJ.2021.v11.i4.22


Turabian Style

Nishimori, Tomohiro, Kiwamu Hanazono, Kazuya Matsuda, Yoshio Kawamura, Tsuyoshi Kadosawa, Yoshifumi Endo, and Tsuyoshi Uchide. 2021. Prognostic role of ΔNp63 expression in canine transitional cell carcinoma of the urinary bladder. Open Veterinary Journal, 11 (4), 700-706. doi:10.5455/OVJ.2021.v11.i4.22


Chicago Style

Nishimori, Tomohiro, Kiwamu Hanazono, Kazuya Matsuda, Yoshio Kawamura, Tsuyoshi Kadosawa, Yoshifumi Endo, and Tsuyoshi Uchide. "Prognostic role of ΔNp63 expression in canine transitional cell carcinoma of the urinary bladder." Open Veterinary Journal 11 (2021), 700-706. doi:10.5455/OVJ.2021.v11.i4.22


MLA (The Modern Language Association) Style

Nishimori, Tomohiro, Kiwamu Hanazono, Kazuya Matsuda, Yoshio Kawamura, Tsuyoshi Kadosawa, Yoshifumi Endo, and Tsuyoshi Uchide. "Prognostic role of ΔNp63 expression in canine transitional cell carcinoma of the urinary bladder." Open Veterinary Journal 11.4 (2021), 700-706. Print. doi:10.5455/OVJ.2021.v11.i4.22


APA (American Psychological Association) Style

Nishimori, T., Hanazono, . K., Matsuda, . K., Kawamura, . Y., Kadosawa, . T., Endo, . Y. & Uchide, . T. (2021) Prognostic role of ΔNp63 expression in canine transitional cell carcinoma of the urinary bladder. Open Veterinary Journal, 11 (4), 700-706. doi:10.5455/OVJ.2021.v11.i4.22


Author LoginReviewer LoginAbout PublisherPublication Ethics and Publication Malpractice StatementConflict of Interest PolicyPlagiarism PolicyTerms of UseLicense Information

About Open Veterinary Journal

Open Veterinary Journal provides a fast track coupled with high quality peer review process for original research articles, review articles, short communi ... Read more.



For best results, please use Internet Explorer or Google Chrome.

Contact Information

All correspondence should be addressed to:

Prof. Ibrahim Eldaghayes: Owner, Founder and Editor-in-Chief

Open Veterinary Journal


Faculty of Veterinary Medicine, University of Tripoli

P.O. Box 13662, Tripoli, Libya

and


Eldaghayes Publisher

www.eldagpublisher.com 

Email: ibrahim.eldaghayes@vetmed.edu.ly