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2025, Vol: 15, Issue: 2
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Research Article


Combined extracts of Curcuma longa and Curcuma zedoaria ameliorates cisplatin-induced kidney damage in rats

Putri Reno Intan, Sukmayati Alegantina, Hidayatul Fajri, Fitrine Ekawasti, Ani Isnawati, Lisa Andriani Lienggonegoro, Uly Alfi Nikmah, Sunarno Sunarno, Sela Septima Mariya, Lina Noviyanti Sutardi, Agus Setiyono, Ekowati Handharyani.


Abstract
Background:
Cisplatin is a highly effective chemotherapeutic drug. However, it is associated with various side effects, including kidney damage, due to its nephrotoxic properties.

Aim:
This study aimed to evaluate the renoprotective potential of the combined extract of Curcuma longa and Curcuma zedoaria in reducing nephrotoxicity by examining its effects on TNF-α, KIM-1, and Caspase-3 levels.

Methods:
Twenty-five rats were divided into normal control groups (NS), cisplatin control groups (CIS), and three treatment groups that received doses of the combined extract at 100, 200, and 400 mg/kg (CUR100, CUR200, and CUR400), respectively on day 1-20. All groups, except the NS group (receiving normal saline i. p.), received intraperitoneal cisplatin (1 mg/kg) on days 7 and 14 of the 20-day extract treatment.

Results:
Compared with the rats in the CIS group, rats given the combined extract had a considerable gain in body weight and decreased TNF-α, KIM-1, and caspase-3 expression levels. Histopathological examination revealed that the extract group experienced less kidney damage than the CIS group. The combined extract, administered at 200 mg/kg, dexertedthe most apparent protective effect, decreasing renal TNF-α, KIM-1,, and caspase 3.

Conclusion:
The combined extract of Curcuma longa and Curcuma zedoaria has the potential to be a therapeutic agent for reducing nephrotoxicity by suppressing TNF-α, KIM-1, and caspase-3 levels. Further research is required to determine the potential of this combination therapy in humans.

Key words: Cisplatin, Curcuma longa, Curcuma zedoaria, Inflammation, Nephrotoxicity


 
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How to Cite this Article
Pubmed Style

Intan PR, Alegantina S, Fajri H, Ekawasti F, Isnawati A, Lienggonegoro LA, Nikmah UA, Sunarno S, Mariya SS, Sutardi LN, Setiyono A, Handharyani E. Combined extracts of Curcuma longa and Curcuma zedoaria ameliorates cisplatin-induced kidney damage in rats. Open Vet J. 2025; 15(1): 428-436. doi:10.5455/OVJ.2025.v15.i1.38

Web Style

Intan PR, Alegantina S, Fajri H, Ekawasti F, Isnawati A, Lienggonegoro LA, Nikmah UA, Sunarno S, Mariya SS, Sutardi LN, Setiyono A, Handharyani E. Combined extracts of Curcuma longa and Curcuma zedoaria ameliorates cisplatin-induced kidney damage in rats. https://www.openveterinaryjournal.com/?mno=225425 [Access: March 12, 2025]. doi:10.5455/OVJ.2025.v15.i1.38

AMA (American Medical Association) Style

Intan PR, Alegantina S, Fajri H, Ekawasti F, Isnawati A, Lienggonegoro LA, Nikmah UA, Sunarno S, Mariya SS, Sutardi LN, Setiyono A, Handharyani E. Combined extracts of Curcuma longa and Curcuma zedoaria ameliorates cisplatin-induced kidney damage in rats. Open Vet J. 2025; 15(1): 428-436. doi:10.5455/OVJ.2025.v15.i1.38


Vancouver/ICMJE Style

Intan PR, Alegantina S, Fajri H, Ekawasti F, Isnawati A, Lienggonegoro LA, Nikmah UA, Sunarno S, Mariya SS, Sutardi LN, Setiyono A, Handharyani E. Combined extracts of Curcuma longa and Curcuma zedoaria ameliorates cisplatin-induced kidney damage in rats. Open Vet J. (2025), [cited March 12, 2025]; 15(1): 428-436. doi:10.5455/OVJ.2025.v15.i1.38


Harvard Style

Intan, P. R., Alegantina, . S., Fajri, . H., Ekawasti, . F., Isnawati, . A., Lienggonegoro, . L. A., Nikmah, . U. A., Sunarno, . S., Mariya, . S. S., Sutardi, . L. N., Setiyono, . A. & Handharyani, . E. (2025) Combined extracts of Curcuma longa and Curcuma zedoaria ameliorates cisplatin-induced kidney damage in rats. Open Vet J, 15 (1), 428-436. doi:10.5455/OVJ.2025.v15.i1.38


Turabian Style

Intan, Putri Reno, Sukmayati Alegantina, Hidayatul Fajri, Fitrine Ekawasti, Ani Isnawati, Lisa Andriani Lienggonegoro, Uly Alfi Nikmah, Sunarno Sunarno, Sela Septima Mariya, Lina Noviyanti Sutardi, Agus Setiyono, and Ekowati Handharyani. 2025. Combined extracts of Curcuma longa and Curcuma zedoaria ameliorates cisplatin-induced kidney damage in rats. Open Veterinary Journal, 15 (1), 428-436. doi:10.5455/OVJ.2025.v15.i1.38


Chicago Style

Intan, Putri Reno, Sukmayati Alegantina, Hidayatul Fajri, Fitrine Ekawasti, Ani Isnawati, Lisa Andriani Lienggonegoro, Uly Alfi Nikmah, Sunarno Sunarno, Sela Septima Mariya, Lina Noviyanti Sutardi, Agus Setiyono, and Ekowati Handharyani. "Combined extracts of Curcuma longa and Curcuma zedoaria ameliorates cisplatin-induced kidney damage in rats." Open Veterinary Journal 15 (2025), 428-436. doi:10.5455/OVJ.2025.v15.i1.38


MLA (The Modern Language Association) Style

Intan, Putri Reno, Sukmayati Alegantina, Hidayatul Fajri, Fitrine Ekawasti, Ani Isnawati, Lisa Andriani Lienggonegoro, Uly Alfi Nikmah, Sunarno Sunarno, Sela Septima Mariya, Lina Noviyanti Sutardi, Agus Setiyono, and Ekowati Handharyani. "Combined extracts of Curcuma longa and Curcuma zedoaria ameliorates cisplatin-induced kidney damage in rats." Open Veterinary Journal 15.1 (2025), 428-436. Print. doi:10.5455/OVJ.2025.v15.i1.38


APA (American Psychological Association) Style

Intan, P. R., Alegantina, . S., Fajri, . H., Ekawasti, . F., Isnawati, . A., Lienggonegoro, . L. A., Nikmah, . U. A., Sunarno, . S., Mariya, . S. S., Sutardi, . L. N., Setiyono, . A. & Handharyani, . E. (2025) Combined extracts of Curcuma longa and Curcuma zedoaria ameliorates cisplatin-induced kidney damage in rats. Open Veterinary Journal, 15 (1), 428-436. doi:10.5455/OVJ.2025.v15.i1.38


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